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an active site is a region that is present on an enzyme where the reactants or the substrate molecules we can say bind and experience a chemical reaction. the substrate is basically a reactant whose concentration is changing and that is converting into a product after binding at the active site of an enzyme

as the gila monster consumes the eggs or young of the desert cottontail and gambel's quail, thus its main food supply is only accessible for a restricted time duration every year. however, for this, the gila monsters exhibit three adaptations, which elevate their survival rate in the desert condition.  

first, is that they possess huge bodies, and can consume greater concentrations of food during a small period. secondly, they require to feed infrequently as they can accumulate fat in their tails. ultimately, their rate of metabolism is very low, so that they can burn their reservoirs of fat gradually.