How does the shape of a protein relate to its function? Refer to specific details about this case and sickle cell anemia

The gene that causes sickle-cell disease is present in a higher percentage of residents of sub-saharan africa than among those of african descent living in the united states. even though this gene causes sickle-cell disease, it also provides some protection from malaria, a serious disease that is widespread in sub-saharan africa but absent in the united states. discuss an evolutionary process that could account for the different percentages of the sickle-cell gene among residents of the two regions.

1. emigration the movement of people from one place to another 2. immigration a situation in which resources are being used up at a faster rate than they can be replenished 3. migration the leaving of one's homeland to settle in a new place 4. overpopulation the movement of people to a new country 5. sustainable development a situation in which the birth rate is not sufficient to replace the existing population 6. underpopulation the ability to meet current needs without reducing the ability to meet future needs 7. unsustainable development the increase in the population of a city 8. urbanization a situation in which the number of people exceeds the available natural resources in an area

Which part of the cell is affected by the movement of molecules through diffusion, osmosis and active transport?