There are almost 500 naturally occurring variants of hemoglobin. Most are the result of a single amino acid substitution in a globin polypeptide chain. Some variants produce clinical illness, though not all variants have deleterious effects. Identify the variant or variants that can be described by each of the three statements by placing the letter corresponding to the statement next to the variant. Statement B may describe more than one variant, and a variant may be described by more than one statement. At least one variant will not match any description. A. The Hb variant least likely to cause pathological symptoms. B. The variants most likely to show pI values different from that of HbA on an isoelectric focusing gel. C. The variant most likely to show a decrease in BPG binding and an increase in overall affinity for oxygen.

Hello. This question is incomplete. You forgot the following answer options:

HbS (sikle-cell HB): substitutes a Val for Glu on the surface.

Hb Memphis:Substitutes onde unchanged polar residue for another of similar size on the surface.

HbMilwaukee: Substitutes a Glu for a Val.

HbPhilly: substitutes a Phe for a Tyr, disrupting hydrogen bondingat the α1β1 interface.

Hb Providence: substitutes an Asn for a Lys that normally decrease in BPG binding and an increase in overall affinity for oxygen B C projects into the central cavity of the tetramer

HbS (sikle-cell HB): substitutes a Val for Glu on the surface.  (B)

Hb Memphis:Substitutes onde unchanged polar residue for another of similar size on the surface. (A)

HbMilwaukee: Substitutes a Glu for a Val. (B)

HbPhilly: substitutes a Phe for a Tyr, disrupting hydrogen bondingat the α1β1 interface. (B)

Hb Providence: substitutes an Asn for a Lys that normally decrease in BPG binding and an increase in overall affinity for oxygen B C projects into the central cavity of the tetramer (BC)

Explanation:

The above phrases reveal information about some of the natural variants of hemoglobin, which as the question above informs, can have more than 500 variants.

Most of these variants occur due to structural changes that were caused by amino acid substitutions within the nucleotide sequences, which ends up modifying the entire protein, often interfering with its functions, depending on the extent of the mutation and where it happened.

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