Which is a pathophysiologic change that is consistent with Alzheimer disease?

The correct answer is - occurrence of  amyloid plaques and neurofibrillary.

Explanation:

Neural thread protein known as tau protein responsible for the stabilization microtubules, in patient of Alzheimer these proteins are chemically modified and tangles or twists into paired helical filaments called neurofibrilary tangles.

In specific region of of brain have strokes which is focal cerebral infarct, Abnormal cholinergic system is associated with this seizure disorder. Amyloid plaques are misfolded proteins aggregates that are present in the space between nerve spaces associated with Alzheimer disease.

Thus, the correct answer is :  occurrence of  amyloid plaques and neurofibrillary