Is climate change man-made or natural

Which entry is in the wrong position in the table?

Agene editing technology called crispr-cas9 uses cellular machinery to change the cell's genetic material. how might this technology be useful in treating diseases like cancer?

The earth formed roughly 4.5 billion years ago, yet evidence of life dates back to about 3.5 billion years ago. which one is not a possible hypothesis of how life on earth arose?