A tumor cell with a mutation in Rb can divide in the absence of extracellular signals. A. If the Rb mutation is responsible for the increased cell division, is it likely that Rb is always active or always inactive

The Rb will always stay active

Explanation:

The Rb, undergoing a mutation that promotes cell proliferation, the cells will proliferate excessively, either benignly or malignant, forming a tumor structure.

The Rb mutation is considered an irreversible process, which will generate an unlimited and excessive growth that is abnormal when compared to the other non-mutated cells.