The rate of a reaction catalyzed by an enzymes usually with temperature; however, at temperatures above the optimum range . The rate of a reaction catalyzed by an enzymes usually with temperature; however, at temperatures above the optimum range . decreases; prosthetic groups are necessary increases; protein denaturation occurs decreases; the reaction proceeds without the enzyme increases; the reaction proceeds without the enzyme increases; the direction of the reaction reverses

increases; protein denaturation occurs

Explanation:

One of the characteristic of enzymes is the sensitivity to temperature .

Enzymes are sensitive to the changes in the environmental temperature.The enzymatic activities increases with increase in temperature,up to the optimum of 37 degrees in most animals.

However,once the optimum temperature has been exceeded,enzyme activities drops.This is because below optimum the rate of collision between the enzyme active sites and substrate molecules is very high,therefore more products are formed which increases the rate of reactions.

At temperature above the optimum,the high temperature  breaks the bonds,especially the hydrogen bonds holding the 3D structure of the active sites.Therefore,substrate molecules can not fit into the active site,and therefore enzymatic actives of the enzyme is affected,and the enzyme is said to be  denatured