3. Mutations that occur in the BPG binding cavity on deoxyhemoglobin can at times result in the substitution of lysine and histidine residues present with aspartic acid and phenylalanine residues. Explain how these changes would impact BPG binding to deoxyhemoglobin along with the impact it would have on oxygen transport with hemoglobin

It affects the oxygenation of the tissues in a negative way, that is, causing tissue hypoxias.

Explanation:

What will happen is that BPG, having a different relationship with deoxyhemoglobin, hemoglobin will not give oxygen to organs or tissues during glycolysis at times when the sympathetic nervous system is activated or even in the maintenance of physiological tissue vitality, therefore it will trigger a drop in the partial pressure of the gas both in the blood and in the tissues since they will be retained in the hemoglobin structure without being able to release it.

the relative atomic mass of an element is the mass of one atom of that element, relative to 1/12th of the mass of a  1212c atom. to convert to an absolute mass in kg, it is necessary to multiply by  1.661×10−271.661×10−27.

the relative atomic mass is roughly equal to the number of neutrons, plus the number of protons, in the nucleus of the atom.

for elements with more than one stable isotope (different types of nucleus with different numbers of neutrons but the same number of protons), the quoted mass is usually the average mass, weighted by the relative abundance of the different isotopes.