Single Antigen, Multiple Organs Some Type-II immunopathology mediated autoimmune diseases have manifestations in multiple different organs. Discuss how antibodies to one single antigen can cause damage in multiple sites throughout the body. Things you might discuss include, but are not limited to where the antigen could be expressed, how antibodies are made, how they bind antigen, where they circulate, the ratios of antigen to antibody, mechanisms of the immune system that result in cellular/tissue damage, or how immune system components can affect other organs. You might also comment on what makes one antigen an attractive target rather than another. Please do NOT comment on all the things listed above, they are just to get you thinking. If you are having trouble getting started, it might help to think about a specific disease which affects multiple organs... Good Luck!

To answer this question, researchers studied populations of the dusky salamander (desmognathus ochrophaeus) living on different mountain ranges in the southern appalachian mountains. the researchers tested the reproductive isolation of pairs of salamander populations by leaving one male and one female together and later checking the females for the presence of sperm. four mating combinations were tested for each pair of populations (a and b)—two within the same population (female a with male a and female b with male b) and two between populations (female a with male b and female b with male a). the proportion of successful matings for each mating combination was measured. for example, when all the matings of a particular combination were successful, the researchers gave it a value of 1; when none of the matings were successful, they gave it a value of 0. then the researchers calculated an index of reproductive isolation that ranged from 0 (no isolation) to 2 (full isolation). the reproductive isolation value for two populations is the sum of the proportion of successful matings of each type within populations (aa + bb) minus the sum of the proportion of successful matings of each type between populations (ab + ba). the table provides data for the geographic distances and reproductive isolation values for 27 pairs of dusky salamander populations.

Regarding most of the narrator’s story, which word best describes the tone?

The third stage of cellular respiration is (2 points)