In the lab, metabolic poisons can be used to study ATP synthesis and oxygen consumption. Many of these poisons have – or have had – other uses, from diet aids to animal poisons to antibiotics. Poison Action oligomycin binds to F0F0 and blocks the proton channel cyanide inhibits cytochrome oxidase by reacting with heme a3 trifluorocarbonylcyanide phenylhydrazone (FCCP)(FCCP) increases membrane proton permeability rotenone blocks electron transfer at NADHNADH dehydrogenase (NAD−Q(NAD−Q oxidoreductase) bongkrekic acid binds to inward‑facing site of ATP‑ADP translocase Classify the metabolic poisons as electron transport inhibitors, uncoupling agents, ATP synthase inhibitors, or transport inhibitors.
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