Keith and Marsha's only child to have a carrier genotype, Jeff, did marry. Cedric remained single due to poor health, and Nita swore off marriage after several bad relationships. Jeff and his wife Adrienne had four children, Angela, Keith, Joyce, and Denise. Although the parents were not expecting it to happen, their only son and their second born girl were born with sickle cell disease. Post- pedigree questions: If you were Ketih and Marsha's genetic counselor, what would you tell them? Which of the Jackson's grandchildren are definitely carriers? What is Adrienne's genotype?

Answer to Question 1:

Sickle cell anemia is a recessive disorder. The fact that one of their children is a carrier means that either of Keith and Marsha is a carrier ot it might be that both of them are carriers of the disease.

Answer to Question 2:

The other two kids of Jeff and Adrienne who don't have the genetic disease are still carriers of sickle cell anemia.

Answer to Question 3:

Adrienne is a carrier of the sickle cell anemia disease as well, just like Jeff.

Hope that answers the question, have a great day!

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