Biology
Biology, 19.05.2020 21:05, sunshine210421

In the lab, metabolic poisons can be used to study ATP synthesis and oxygen consumption. Many of these poisons have – or have had – other uses, from diet aids to animal poisons to antibiotics.

Poison Action
oligomycin binds to F0 and blocks the proton channel
carbon monoxide inhibits cytochrome oxidase by reacting with heme a3
trifluorocarbonylcyanide-
phenylhydrazone (FCCP) increases membrane proton permeability
antimycin prevents electron flow between cytochrome b and
cytochrome c
bongkrekic acid binds to inward‑facing site of ATP‑ADP translocase

Classify the metabolic poisons as electron transport inhibitors, uncoupling agents, ATP synthase inhibitors, or transport inhibitors.

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