Acetazolamide is a diuretic that blocks the activity of the enzyme carbonic anhydrase inside kidney tubule cells. This blockage prevents the formation of carbonic acid from carbon dioxide and water. Normally carbonic acid dissociates to form hydrogen ions and bicarbonate ions, and the hydrogen ions are exchanged for sodium ions from the urine. Blocking the formation of hydrogen ions in the cells of the nephron tubule blocks sodium reabsorption, inhibiting water reabsorption and producing the diuretic effect.
a) With this information in mind, what effects would acetazolamide have on blood pH, urine pH, and respiratory rate?
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Acetazolamide is a diuretic that blocks the activity of the enzyme carbonic anhydrase inside kidney...
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