The role that p53 protein plays in suppressing inappropriate progression through the cell cycle depends on all of the following except .

Options are not provided in the question. The complete question is as following:

The role that p53 protein plays in suppressing inappropriate progression through the cell cycle depends on all of the following EXCEPT .

A) p53 indirectly blocks G1 to S transition in the cell cycle

B) p53 activates transcription of WAF1

C) p53 stability increases in the presence of unrepaired DNA lesions

D) the ability of p53 to bind DNA lesions

D) the ability of p53 to bind DNA lesions

Explanation:

The activities of the protein p53 are dependent on its binding DNA. Specific post-translational modifications to the p53 protein are important for efficient sequence-specific binding and transcription activities. Non-sequence-specific DNA binding can involve a broad range of p53 proteins and predominate as more serious DNA damage or greater induction of p53 protein. P53 Protein is not strictly essential for sensing and repairing DNA damage. Alternatively, p53 protein can control an apoptosis checkpoint by competing with DNA repair proteins for non-sequence-specific binding in the DNA duplex to exposed single-stranded regions.

Hence, while suppresing inappropriate progression through the cell cycle protein p53 does not bind to DNA lesions.

Hence, the correct option is D.

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