16-16: In a series of experiments, genes that code for mutant forms of an RTK are introduced into cells. The cells also express their own normal form of the receptor from their normal gene, although the mutant genes are constructed so that the mutant RTK is expressed at considerably higher concentration than the normal RTK. What would be the consequences of introducing a mutant gene that codes for an RTK (A) lacking its extracellular domain, or (B) lacking its intracellular domain

(A) lacking its extracellular domain:

RTK receptors can bind to the ligand, this phenomenon leads to a decrease in the rate of molecular interaction between receptors and ligands.

(B) lacking its intracellular domain:

RTK receptors can not bind to the ligand and therefore they are inactive, this phenomenon doesn't have effects on the receptor-ligand interaction mechanism

Explanation:

These types of experiment are very important in molecular biology since they enable to determine the function of transmembrane proteins in molecular signaling pathways

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