The citric acid cycle is a stage of catabolism that oxidizes acetate into carbon dioxide and generates energy. There are eight enzymes involved in the citric acid cycle.

Which enzymes produce carbon dioxide as a product?

A. malate dehydrogenase
B. isocitrate dehydrogenase
C. α‑ketoglutarate dehydrogenase
D. succinate dehydrogenase

Isocitrate dehydrogenase and α‑ketoglutarate dehydrogenase are the two enzymes that produces carbon dioxide as a by-product.

Explanation:

The release of carbon dioxide from any compound is known as decarboxylation. The first step where carbon dioxide is released as a by product is when Isocitrate is oxidized and decarboxylated to α‑ketoglutarate and this reaction is catlyzed by isocitrate dehydrogenase. The second step where carbon dioxide is released as a by product is from decarboxylation of   α‑ketoglutarate into succinyl-Co A and this reaction is catalyzed by α‑ketoglutarate dehydrogenase.

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