The hives that Sally is experiencing are a result of an anaphylactic reaction. This is a multistep reaction resulting from the interaction of the wasp venom and Sally's immune system. Each of the statements below is a step in the anaphylactic response.

Arrange the following statements in the order that best represents the chronological order of events in generating an anaphylactic reaction.

1.IgE molecules bind to mast cells and basophils.
2. Antigen molecules cross-link adjacent IgE molecules.
3. Degranulation occurs.
4. Chemical mediators such as histamine are released.
5. Capillary permeability and smooth muscle contractions increase.
6. Neutrophils and eosinophils move to the site.

The correct sequence is 1, 2, 3, 4, 5 and 6.

Explanation:

An extreme allergic reaction to food, venom, or medicine is termed as anaphylaxis. However, the majority of the cases of anaphylaxis occur due to the consumption of foods like tree nuts or peanuts or by stinging of a bee. Some of the signs of the condition are low pulse, rashes, and at certain occasions shock, also called anaphylactic shock.  

The following is the chronological order of the events that take place during the generation of an anaphylactic reaction are:  

1. The binding of the IgE molecules takes place with the basophils and mast cells.  

2. The cross-linking takes place between the antigen and the neighboring IgE molecules.  

3. The process of degranulation takes place.  

4. Discharging of chemical mediators like histamine takes place.  

5. An elevation in smooth muscle contractions and capillarity permeability is witnessed.  

6. Finally, the eosinophils and neutrophils move towards the affected region.  

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