Please choose whether you AGREE or DISAGREE with the following statement, and provide your reasoning:
"Switching the flanking charges around transmembrane domain 1 will flip the orientation of this protein in the plasma membrane." (In other words, if the N-terminal domain was originally in the cytoplasm, it will now be in the extracellular space. Or if the N-terminal domain was originally in the extracellular space, it will now be in the cytoplasm.)