ORFs in eukaryotes are hard to identify from genomic DNA because: Group of answer choices
eukaryotic genes are sometimes methylated
they are disrupted by introns
eukaryotic genes code for much larger proteins
eukaryotic genes have extensive histone modifications

They are disrupted by introns

Explanation:

Open reading frames are defined as the base pair sequence between the start and stop codon in an mRNA. The open reading frames are important from the translation point of view as this is the sequence that can be translated into proteins.

In eukaryotes, the identification of an open reading frame is very difficult as the sequence contains the introns or non-coding sequence which makes it difficult. Therefore the cell must remove these introns from the sequence.

Thus, the selected option is correct.