Cell Signaling: Transduction and Response C 1 of 16 The histamine H1 receptor is one of several existing histamine G protein-coupled receptors. Depending on many factors, including the type of receptor histamine can trigger a variety of responses, including vasodilation, smooth muscle contraction, stimulation of gastric secretion, cardiac stimulation, and increased vascular permeability (causing runny nose and watery eyes). Which of the following could account for the different cellular responses to histamine? Select all that apply. View Available Hint(s) O the types of relay molecules within the cell the enzyme that is activated by the G protein associated with the receptor O the type of second messengers involved in the signal transduction pathway the cell type in which the histamine receptor is located the type of signaling molecule