Gene expression from the lac operon can be controlled in many ways, including a robust negative regulation strategy Select mutations that would reduce the effectiveness of this negative regulation and increase lac operon activity. □ □ □ □ □a. mutation that deletes the lacI geneb. mutation of the-10 promoter sequence to more closely resemble the E. coli consensus sequence c. mutation that increases the affinity of the operator regions for lactose repressor d. mutation that reduces the affinity of the lactose repressor for lactosee. mutation of the-10 promoter sequence to be less similar to the E. coli consensus sequence

Mutation that reduces the affinity of the lactose repressor for lactose.

Explanation:

The operon model is operated in prokaryotes for the regulation of gene expression. The lac operon is active for the metabolism of the lactose and the genes that are associated with the metabolism.

The repressor molecule regulates the expression of the Lac operon. This repressor molecule binds with the DNA sequence tightly and blocks the transcription. The mutation that results in the decrease ability or affinity for the lactose might results in the continuous expression of the gene.

Thus, the correct answer is option (d).

the correct option is option d