There is a mutation in the rate limiting enzyme which prevents it from binding its substrate. How will this mutation affect the cholesterol biosynthetic pathway, when cholesterol levels are high in the organism?

In the cholesterol biosynthetic pathway, the rate-limiting step is the reduction of HMG-CoA, which takes place in the existence of the HMG-CoA reductase enzyme. In case, when mutation takes place within the mentioned enzyme, it loses the tendency to combine with the substrate HMG-CoA, and as a consequence, the pathway fails to move forward and synthesis of cholesterol stops.  

When the levels of cholesterol are high within the organism than the mutation of the enzyme HMG-CoA reductase results in less synthesis of cholesterol within the body of the organism and will eventually assist in balancing the level of cholesterol present within the body.  

ecological efficiency: % of usable energy transferred as

biomass from one trophic level to the next typical is 10% efficient (90% of

energy is lost),is diagramed as the pyramid of energy flow. then osprey eagle

are tertiary consumer and the shrimp are primary consumer, so to balance

mass of shrimp (1/0.1) / 0.1 = 100 kg 

we need additional information in order to determine the cause of death for anna garcia. there are at least 3 things with explanation included as to why we need them are as follows: