In many tissues, one of the earliest responses to cellular injury is a rapid increase in the level of enzymes involved in the pentose phosphate pathway. Ten days after an injury, heart tissue has levels of G6PD and 6-phosphogluconate dehydrogenase that are 20 to 30 times higher than normal, whereas the levels of glycolytic enzymes are only 10 to 20% of normal. Suggest an explanation for this phenomenon.
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