Fumarase is the enzyme that catalyzes the following reaction between fumarate and water to produce malate in cells. Which statement can be used as evidence that orientation of reactant molecules is part of the function of fumarase as a catalyst?

a. The active site of fumarase contains a histidine and a lysine that function as an acid and a base, respectively, during catalysis.

b. Fumarase does not use a coenzyme but requires one Fe2+ ion at its active site.

c. Fumarase binds one fumarate molecule and one water molecule the same way for every reaction.

d. Mutation of the active site lysine to other amino acids obliterates or severely reduces activity in fumarate.

e. Fumarase catalyzes both the forward and reverse reactions between fumarate and malate.

Hurry i need your (100 points) 1) what are the responsibilities of the region of the brain highlighted below? (picture located below) the highlighted portion is at the rear base of the brain, behind the brain stem. regulating homeostasis, hunger and eating, thirst and drinking, and many other functions of basic survival. coordinating movement and balance by using information from sensory nerves, including hand-eye coordination. controlling voluntary body movements, processing information from sense organs, thoughts, and learning abilities. regulating important involuntary bodily functions such as blood pressure, heart rate, breathing, and swallowing. 2)which of the following systems or structures is correctly paired with its function? neurons - brain cells that control thoughts, calculations, and memory cerebral cortex - portion of the brain that controls involuntary body movement peripheral nervous system - carries impulses to and from the central nervous system central nervous system - carries information from the nerves to the muscles and glands

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