Why would a mutation that involves a centromere have a greater impact than a mutation that occurs elsewhere on a chromosome?

Which of the following statements is true regarding a basic amino acid? a.) the hydrophilic r group of a basic amino acid will be located on the interior of a protein b.) the positively charged r group of a basic amino acid could bind dna c.) the r group of a basic amino acid would only be able to form covalent bonds with other molecules d.) a basic amino acid would be considered both polar and hydrophobic e.) all of the above