Modification of these cells would not affect the genetic make-up of one’s

Somatic cells

Explanation:

Alteration done to somatic cells would impact that person's body only—and cannot be inherited.

On the other side, germline cells are procreative cells that can produce embryos. Therefore, any alterations to this ones will be hereditary.

Somatic genetic modification alters the genes in order to provide solution to a medical condition.

Gametes, or sex cells, are produced out of germ cells, while somatic cells are all the cells except sex cells. A mutation that affecsts the germ cells, its termed a germline mutation.

Modification of somatic cells would not affect the genetic make-up of one’s children