Which action(s) could contribute to the positive inotropic effect of digoxin on cardiac myocytes?

The question is incomplete as it lack the options. The multiple options are as follows;

I. Decrease transport of Ca2+ to the extracellular environment.

II. Increase availability of intracellular Ca2+ to bind to troponin.

III. Increase overall Ca2+ stores in the sarcoplasmic reticulum.

A.II only

B.III only

C.I and II only

D.I, II, and III

I, II, and III.

Explanation:

Digoxin is the drug used for the treatment of the heart failure patients. This drug is also used for the proper regulation of the heart beat and maintains the individual ability of walk.

The digoxin shows the positive effect on the cardiac myocetes. This drug decreases the calcium transport in the extracellular fluid and increases the intracellular calcium level that binds to troponin. This drug also increases the stored calcium level of the sarcoplasmic reticulum. These steps will helps in the contraction of the heart cells and increase the calcium level.

Thus, the correct answer is option (D).

you are certainly talking about this picture:

a: is the label of the white square, it is showing the  replication fork, formed by helicase (d) ==> so it is the site of dna separation and replication 

b: is a new dna brand that is following directly the replication fork, so it is continuous ==> built continuously from 5' to 3

c: dna polymerase cannot replicate dna on its own, it needs the of their proteins, and one of them plays the role of a clamp which fixes  the dna with the dna template and increases  the processivity of the enzyme. ==>   stops polymerase from falling off the  template.

d: is the enzyme responsible for forming the replication fork (helicase) ==> unwinds and separates dna into two strands

e: is the delayed strand, it is built  in the opposite sense of the helicase, so dna will be built in fragments ==> built  fragments from 5' to 3 joins

and finally f: is the enzyme that builds  the new dna strand (dna polymerase) ==>   adds nucleotides to make a new dna helix.

credit: gradman555p98x9p

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