Rank the following one-base-point mutations (from most likely to least likely) with respect to their likelihood of affecting the structure of the corresponding polypeptide:

1. insertion mutation deep within an intron
2. substitution mutation at the third position of an exonic codon
3. substitution mutation at the second position of an exonic codon
4. deletion mutation within the first exon of the gene

6. in domesticated cats, the following are independently assorting: normal ears (t) is dominant to tufted ears (t); curved whiskers (c) is dominant to straight whiskers (c); the presence of six toes (s) is dominant to five toes (s); gene for hair length is an x-linked codominant. the three phenotypes for hair length are long (xhxh), medium (xhxh), and short (xhxh); medium is the heterozygous condition. given two parents: ttccssxhxh x ttccssxhy how many different gametes could be formed in the female cat with respect to these four traits? how many phenotypes are possible in the offspring from this mating?

What determines whether a particular cell is able to respond to a hormone?

Could anybody give me the answer to this question.