After injecting the mice with both bacteria, what question did griffith ask him self

Griffith performed an experiment on the mice to test two different strains of bacteria. One of them was virulent and the other was non virulent. The result depicted that the non virulent strain transformed into virulent strain through the process of transformation.

Explanation:

Different mice were injected with different combination of strains. One of the strain was a virulent one, III-S and the other one was II-R which was non virulent. Both the strains were taken from Streptococcus pneumoniae. The following observations were made:

1. In the first mice only simple III-S was introduced. The mouse died.

2. In the second one, heat killed III-S was injected. The mouse survived as the virulent portion was killed.

3. In this one II-R was introduced. Since it was an non virulent strain, the mice did not die.

4. In this he added both heat killed III-S and II-R. The mouse died and this perplexed Griffith. He wondered what had happened since the non virulent form and heat killed virulent form should have not harmed the mice.

Later he found out that the DNA of the Heat killed III-S was imbibed by the II-R form. The bacteria had 'transformed' and as a result the mice died.