Which option best represents the ideal characteristics of drugs for use in low- and middle-income countries?

a. easy to transport and store, injectable, heat sensitive, single dose
b. bulky, oral administration, heat sensitive, multiple doses
c. easy to transport and store, oral administration, heat stable, single dose
d. easy to transport and store, oral administration, heat sensitive, single dose

Astudy by solloch and et. al., in 2017, gives the map above which shows the frequency of alleles with a ccr5-delta32 mutations over 87 different countries. this mutation deletes the presence of a co-receptor (ccr5) on the outside of human t-cells (lymphocytes). some viruses, such as the one responsible for the black death and human immunodeficiency virus (hiv), require this receptor for attachment to host cells during the infection process. the black death was an epidemic that passed over northern europe during the 14th century killing nearly 60% of europeans. according to this information, which explanation best explains why northern europeans show a greater immunity for hiv than some other parts of the world?