Biology, 13.12.2019 19:31, littleprinces
The cftr protein is a abc transporter protein that functions at the plasma membrane of epithelial cells. numerous mutations in the cftr gene that have been associated with the disease cystic fibrosis (cf). the most common cf-causing mutation is deletion of phenylalanine 508 (f508del). this mutation causes the cftr protein to misfold such that it is degraded as soon as it is made. the protein fails to be targeted to the plasma membrane, the required location for proper function.
some of the symptoms observed in cf patients are:
i. thick mucus secretions in the lungs (due to a lack of water secretion from epithelial cells into the lung airway space)
ii. blocked pancreatic ducts due to thick mucus secretions
a. what is the normal function of the cftr protein?
b. why do mutations in the cftr protein result in the thick mucus secretions?
c. which classes of cf drugs can treat patients with f508del cftr mutations?
Answers: 3
Biology, 22.06.2019 02:10, alexusnicole817
Draw the structure of dna nucleotide with adenine as nitrogenous base
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Biology, 22.06.2019 04:00, paigefields2578
The wings of insects, birds, and bats evolved independently but carry out similar functions. this is an example of a. analogous structures. b. embryonic structures. c. vestigial structures. d. homologous structures.
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