Systemic fungal infections (e. g. candida and cryptococcus) and tuberculosis (mycobacterium) are on the rise. one of the reasons these organisms have high virulence is that they fare better following macrophage phagocytosis than other microorganisms. phagocytosis activates the glyoxylate cycle in fungi and mycobacteria, allowing them to use two-carbon substrates to sustain growth in an otherwise nutrient-poor environment of the phagolysosome.

a) suggest some likely molecules that could be processed through the glyoxylate cycle in this circumstance.

b) what enzymes are unique for this cycle?

c) does the glyoxylate cycle exist in animals? why?