Sickle cell disease (scd) is found in numerous populations whose ancestral homes are in the malaria belt of africa and asia. scd is an autosomal recessive disorder that results from homozygosity for a mutant β-globin gene allele. data on one affected population indicates that approximately 9 in 100 newborn infants have scd.

p=0.7, q=0.3

epidemiologic data on the population in the previous problem reveal that before the application of modern medical treatment, natural selection played a major role in shaping the frequencies of alleles. heterozygous individuals have the highest relative fitness; and in comparison to heterozygotes, those who are ? a? a have a relative fitness of 83 percent, but only about 16 percent of those with scd survived to reproduce.

1. what is the estimated equilibrium frequency of ? a in this population?

2. what is the estimated equilibrium frequency of ? s in this population?