How do sulfonylureas and meglitinides to lower blood glucose levels?
a) promoting beta cell secretion of insulin
b) decreasing the insulin sensitivity of the receptor cell
c) increasing glucose formation from liver glycogen
d) decreasing deamination of protein

The correct answer is B decreasing the insulin sensitivity of the receptor cell.

Explanation:

Sulfonylureas and meglitidines are used for the treatment of diabetes.These drugs exerts their action by decreasing the insulin sensitivity of the receptor cell.

   As a result the secreted insulin from beta cells of pancreas can easily binds to the insulin receptor in the target cell.The binding of insulin to the receptor helps in the activation of receptor.

       The activated receptor then further activates various enzymes that helps in the utilization of glucose by various body cells there by the decreasing the plasma glucose level.

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