Can a protein that is not part of the cell membrane diffuse through the membrane? if not, why?

Solutes dissolved in water on either side of the cell membrane will tend to diffuse down their concentration gradients, but because most substances cannot pass freely through the lipid bilayer of the cell membrane, their movement is restricted to protein channels and specialized transport mechanisms in the membrane. Although ions and most polar molecules cannot diffuse across a lipid bilayer, many such molecules (such as glucose) are able to cross cell membranes. ... Channel proteins form open pores through the membrane, allowing the free passage of any molecule of the appropriate size.t is the proteins, therefore, that give each type of membrane in the cell its ... Many extend through the lipid bilayer, with part of their mass on either side Many hydrophobic membrane proteins can be solubilized and then purified in an active, if not entirely Many Membrane Proteins Diffuse in the Plane of the Membrane.

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