You are interested in developing an inhibitor for the estrogen receptor. you have identified a molecule that is small and hydrophilic. in a test tube, this inhibitor binds tightly to the estrogen receptor, and inhibits the interaction of the receptor with estrogen. do you think that this molecule will be an effective inhibitor of the estrogen receptor in cells?

The molecule will not be effective inhibitor of estrogen receptor in cells because the molecule that is being generated to act as estrogen inhibitor is hydrophilic.

Explanation:

Estrogen is a steroid hormone synthesized from cholesterol by the ovaries.Estrogen receptor belongs to the family of intracellular receptor or nuclear receptor.

                  Estrogen receptor are located in the nucleus of the target cell.In the  question  it was mention that the identified molecule is hydrophilic  as a result  it will unable to cross the plasma membrane  to bind with the estrogen receptor.

         From that point of view it can stated that the identified hydrophilic molecule cannot act as an effective receptor in vivo or inside the cells.

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