Addition of the drug colchicine to cultured fibroblast cells inhibits movement of transport vesicles. addition of the drug colchicine to cultured fibroblast cells inhibits movement of transport vesicles. colchicine is a drug that prevents microfilament assembly, thereby disrupting microfilament-based functions. colchicine is a drug that prevents intermediate filament assembly, thereby disrupting intermediate filaments-based functions. colchicine is a drug that prevents microtubule assembly, thereby disrupting microtubule-based functions. colchicine is a drug that prevents endocytosis, thereby disrupting phagocytic functions.