Achange in dna resulting in an incorrect protein is the problem in sickle cell disease. is this normally the problem in genetic diseases?

Sickle cell disease in an autosomal recessive inherited disease which is caused by the mutation in the HBB (hemoglobin-β gene) gene present on the chromosome no. 11. In sickle cell, the red blood cells become sickle shape due to the abnormal shape of hemoglobin present in it.

These sickle cells are known to form a blockage in the blood vessels thereby causing damage to the vital organs. Human spleen constantly destroys sickle cells because they get trapped in it which causes a disease called sickle cell anemia.

Sickle cell anemia is normally the problem in genetic disease which is inherited from the parents to children. When both the DNA strand has a mutation in their HBB gene then only this disease will affect the individual.  

economic impact of malaria is estimated to cost africa $12 billion every year. this figure factors in costs of health care, absenteeism, days lost in education, decreased productivity due to brain damage from cerebral malaria, and loss of investment and tourism.

enzyme active site and substrate specificity

enzymes bind with chemical reactants called substrates. there may be one or more substrates for each type of enzyme, depending on the particular chemical reaction. in some reactions, a single-reactant substrate is broken down into multiple products