Adna variant has been found linked to a rare auto-somal dominant disease in humans and can thus be used as a marker to follow inheritance of the disease allele. in an informative family (in which one parent is heterozygous for both the disease allele and the dna marker in a known chromosomal arrangement of alleles and his or her mate does not have the same alleles of the dna variant), the reliability of such a marker as a predictor of the disease in a fetus is related to the map distance between the dna marker and the gene causing the disease. imagine that a man affected with the disease (genotype dd) is heterozygous for the vi and v2forms of the dna variant, with form vi on the same chromosome as the d allele and form v20n the same chromosome as d. his wife is v3v3 dd, where vb is another allele of the dna marker. typing of the fetus by amniocentesis reveals that the fetus has the v2and v3variants of the dna marker. how likely is it that the fetus has inherited the disease allele d if the distance between the d locus and the marker locus is (a) 0 m. u. (b) 1 m. u., (c) 5 m. u. (d) 10 m. u. (e) 50 m. u.?
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