How does nf-îºb induce gene expression?
a small, hydrophobic ligand binds to nf-îºb, activating it.
phosphorylation of the inhibitor iîº-b dissociates the complex between it and nf-îºb, and allows nf-îºb to enter the nucleus and stimulate transcription.
nf-îºb is phosphorylated and is then free to enter the nucleus and bind dna.
nf-îºb is a kinase that phosphorylates a transcription factor that binds dna and promotes protein production.