Test your understanding of the term denaturation by deciding which of the following statements are true. 1- protein denaturation involves cleavage of its peptide bonds. 2- denaturation of an enzyme will cause a loss of its catalytic activity. 3- denaturation and digestion refer to the same process. 4- a denatured protein has a different primary structure than its native state. 5- a denatured protein has a different tertiary structure than its native state.