Discuss the advantages of nmr for drug identification analysis

Nuclear magnetic resonance (NMR) has the following advantages in drug identification and analysis: (1) the sample preparation method is simple: NMR sample pretreatment has few links and is convenient for quality control, thus the sample preparation cost is low and the risk of sample pollution and loss is small; (2) Synchronization of identification and detection: identification and quantitative detection of substances are two separate links in the process of some conventional drug analysis and detection. NMR experiments can provide information on the structure and content of substances at the same time. The identification and content determination of substances in a sample (even an experiment) can be completed by preparing a sample. Therefore, NMR technology is an efficient and rapid detection method. (3) Universality of organic matter: Nuclear magnetic resonance experiment (especially 1H NMR experiment) is a non-biased testing method, which can realize simultaneous identification and analysis of multiple components in the mixture, providing a relatively loose space for the selection of reference materials in quantitative analysis; (4) Strong isomer analysis ability: The unique recognition ability of NMR to isomers is incomparable to many testing technologies (such as chromatography and mass spectrometry). In addition, as a "non-destructive" and low-consumption detection technology, nuclear magnetic resonance testing requires almost no additional consumables except sample preparation reagents, and the samples can be recovered without damage, thus nuclear magnetic resonance is an economical and environment-friendly detection technology.

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