From the list below, which event leads to activation of nf-κb?
question 1 options:
a)
selectin binding
b)
s-lex interactions
c)
integrin activation
d)
tlr activation
e)
icam activation

(D) . TLR activation.

Explanation:

Nuclear factor kappa light chain enhancer of activated B cells (NF-κB) represents a protein complex, which plays various roles in activation of adaptive and innate immune response.

TLRs (toll-like receptors) are specific pattern recognition molecules found in pathogens that triggers immune responses. TLR activation stimulates activation of NF-κB signalling by triggering a downstream signaling cascades.

Activation of NF-κB signalling leads to upregulation of various pro-inflammatory substances or cytokines.

Thus, the correct answer is option (D).