Which of the following is not a way in which an enzyme can speed up the reaction that it catalyzes? the active site of the enzyme can provide a microenvironment that facilitates the reaction. the enzyme can heat the substrate. the enzyme binds a cofactor that interacts with the substrate to facilitate the reaction. the binding of two substrates in the active site provides the correct orientation for them to react to form a product. binding of the substrate to the active site can stretch bonds in the substrate that need to be broken.