The drug tacrolimus is used to prevent transplant rejection. predict the mechanisms of action of tacrolimus.

The kidney filters potentially toxic substances in the blood, and thus “clears” the blood of those substances. this clearance function is dependent upon and proportional to the diffusion gradient of the substance across filtering capillaries, i. e. if the concentration of the substance is doubled, twice as much will be cleared from each ml of blood that is filtered. suppose that the body produces a constant amount of a substance x per unit of time. the kidneys eliminate substance x at a rate directly proportional to the concentration of the substance and the volume of blood cleared each minute (c): elimination = c × [x], where [x] is the steady-state concentration of substance x. imagine an individual with an initial concentration of x equal to [x]0 who develops kidney disease. her baseline clearance c0 drops to one half of the original (½c0). what is the new steady state concentration of x? (for simplicity, assume that substance x is 100% filtered by the kidney).

The blue particles in this image are able to cross the cell membrane through simple diffusion. how will they be transported? outside the cell inside the cell o a. the substances will move directly across the membrane from outside the cell to inside the cell. b. the substances will move through channels in the membrane proteins from outside the cell to inside the cell. o c. the substances will move through channels in the membrane proteins from inside the cell to outside the cell. o d. the substances will move directly across the membrane from inside the cell to outside the cell.

3differences between bacteria and other 2 cells