Biology
Biology, 11.12.2019 09:31, monicagalarza

Dyskeratosis congenita (dkc) is a rare genetic disorder characterized by abnormal fingernails and skin pigmentation, the formation of white patches on the tongue and cheek, and progressive failure of the bone marrow. an autosomal dominant form of dkc results from mutations in the gene that encodes the rna component of telomerase. tom vulliamy and his colleagues examined 15 families with autosomal dominant dkc (t. vulliamy et al., 2004, nature genetics 36: 447–449). they observed that the median age of onset of dkc in parents was 37 years, whereas the median age of onset in the children of affected parents was 14.5 years. thus, dkc in these families arose at progressively younger ages in successive generations, a phenomenon known as anticipation. the researchers measured telomere length of members of these families; the measurements are given in the adjoining table. telomere length normally shortens with age, and so telomere length was adjusted for age. note that the age-adjusted telomere length of all members of these families is negative, indicating that their telomeres are shorter than normal. for age-adjusted telomere length, the more negative the number, the shorter the telomere. how does telomere length of the parents compare with telomere length of the children? explain wiry the telomeres of people with dkc are shorter than normal explain why dkc arises at an earlier ago in subsequent generations

answer
Answers: 1

Other questions on the subject: Biology

image
Biology, 21.06.2019 15:20, Simplytaylorgrenade
Are substances released into the environment that in excess amounts cause damage
Answers: 1
image
Biology, 22.06.2019 09:30, nsbegay2007
Which are reasons cells undergo cell division?
Answers: 1
image
Biology, 22.06.2019 13:00, minecrafter3882
Why is the statement not a hypothesis? sunflowers require soil and plenty of sunlight and water to grow and thrive.
Answers: 3
image
Biology, 22.06.2019 21:00, krojas015
In the controversial scientific process of cloning, organisms are created that are genetically identical to there parent. this process would be classified as
Answers: 2
Do you know the correct answer?
Dyskeratosis congenita (dkc) is a rare genetic disorder characterized by abnormal fingernails and sk...

Questions in other subjects:

Konu
English, 30.11.2021 19:50
Konu
Social Studies, 30.11.2021 19:50