Which type of change would be more likely to have se­vere consequences—substitution or deletion? why?

While both will equate changes in a genetic chain, deletion would have more severe consequences.  A substitution mutation usually only causes minor disorders and diseases, like sickle cell anemia.  Whereas deletion causes much more serious diseases, like cystic fibrosis, and turner syndrome which is  where a female is born with only one X chromosome.  

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