What are some examples of a systematic science excitement vs. a non systematic science experiment? how being systematic or not affect the outcome of the expirement?

Red blood cells are responsible for transporting oxygen in the blood. people with sickle cell anemia were born with a defective gene that results in sickle-shaped red blood cells. individuals with the disease often suffer pain in their extremities due to the build-up of these cells causing blockages in the blood vessels. the shape of the blood cells also reduces the amount of oxygen transported in the blood.