Damage to and blood vessels can cause lack of feeling in the extremities resulting in amputations.

Nerve

Damage to nerve and blood vessels can cause lack of feeling in the extremities resulting in amputations.

Nerves are cable-like bundle of axons and specialized cells (neurons) which make up the nervous system. Nerves transmit messages as electrical signals from one area of the body to another. Nerves are classified into three groups based on the area that messages are conducted. They include; afferent nerves, efferent nerves, and mixed nerves which contain both afferent and efferent axons.

Answer;

-Nerve

Damage to nerve and blood vessels can cause lack of feeling in the extremities resulting in amputations.

Explanation;

-Conditions such as High blood sugar levels caused by diabetes can damage the nerves and blood vessels in the body. That includes the ones in the feet and legs. If the nerves are damaged, one might not feel pain or other symptoms of ulcers or infections.

-Numbness in the feet due to diabetic neuropathy (nerve damage) can make people less aware of injuries and foot ulcers. These ulcers may fail to heal, which can in turn lead to serious infections.