Chronic myeloid leukemia (cml) is a genetic disorder associated with the philadelphia chromosome. the philadelphia chromosome is a mutation in chromosome 22. part of chromosome 22 is exchanged with part of chromosome 9, bringing together two genes on chromosome 22 and causing a malignancy. what type of mutation occurs in the philadelphia chromosome?

The mutation in Philadelphia chromosome is a translocation, identified as, t(9;22)(q34;q11). This abnormal chromosome has a fusion gene, consisting of the ABL gene and the BCR gene, producing the BCR-ABL oncogene. This oncogene produces an enzyme that has a constitutive, abnormal tyrosine kinase activity. The existence of this fusion gene is necessary and sufficient for the generation of leukemia.